NCOG-31. ROLE OF AGE IN CSF LEAK FOLLOWING TRANSSPHENOIDAL RESECTION OF CRANIOPHARYNGIOMA: ANALYSIS OF OUTCOMES IN PEDIATRIC VERSUS ADULT POPULATION

Abstract Postoperative cerebrospinal fluid (CSF) leak is a serious complication after surgical treatment of craniopharyngioma. The objective this study to analyze postoperative CSF rates following transsphenoidal resection craniopharyngioma in adult versus pediatric patient populations. PRISMA guidelines were used query the Pubmed, Web Science, and Cochrane databases for studies or patients from past three decades. search terms, ("craniopharyngioma") AND ("cerebrospinal fluid" OR "CSF") ("leak" "rhinorrhea") ("resection" "surgery") ("transsphenoidal" "endonasal"), used. primary outcome variable collected was presence leak. Pooled analyses performed determine cases. In addition, meta-analysis compare cohort. Of 21 included studies, 8 reported cases, 9 4 both total 468 majority level evidence (90.5%, 19/21), while two 3 (9.5%, 2/21). Analysis cases revealed 29% (95% CI: 21%-39%) 13% 9%-19%), respectively. Using random-effects model, we found that there no significant difference between cohorts (RR: 1.56; 95% CI = 0.52-4.71; P 0.43). present first undergoing craniopharyngiomas. While patients, further higher methodological quality are warranted provide better understanding profiles